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Clomifene Citrate Capsules

Clomifene Citrate Capsules

Place of Origin : china
Price : 15
Packaging Details : 50mg*20pills
Delivery Time : send products out in 24 hours after payment down, 4-7 days products arrive
Payment Terms : Western Union, Paypal or Bank Transfer(T/T)
Supply Ability : 10,0000kits/month
MOQ : 1 box
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Product name: ClomifeneCitrateCapsules

MOQ: 1 Box

Specification: 50mg*20pills/box

Status: Brand new, expiration date in 3 years

Shipping Courier: EMS, DHL to your door, support reship.

Delivery time: send products out in 24 hours after payment down, 4-7 days products arrive.

Packing Methods: Carefully packed into Carton box

Payment Methods: Western Union, Bank Transfer, Money Gram

OEM Service: can do customer person label and package the product as the customer's requirement.

Attention: Pls remember to add your email address in the inquiry, so we can reply whole products category direct to your email, thanks.

Name: Clomifene inhibits estrogen receptors in hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic–pituitary–adrenal axis.[1] Zuclomifene, a more active isomer, stays bound for long periods of time.

In normal physiologic female hormonal cycling, at 7 days past ovulation, high levels of estrogen and progesterone produced from the corpus luteum inhibit GnRH, FSH and LH at the hypothalamus and anterior pituitary. If fertilization does not occur in the post-ovulation period the corpus luteum disintegrates due to a lack of beta-hCG. This would normally be produced by the embryo in the effort of maintaining progesterone and estrogen levels during pregnancy.

Therapeutically, clomifene is given early in the menstrual cycle. It is typically prescribed beginning on day 5 and continuing for 5 days. By that time, FSH level is rising steadily, causing development of a few follicles. Follicles in turn produce the estrogen, which circulates in serum. In the presence of clomifene, the body perceives a low level of estrogen, similar to day 22 in the previous cycle. Since estrogen can no longer effectively exert negative feedback on the hypothalamus, GnRH secretion becomes more rapidly pulsatile, which results in increased pituitary gonadotropin (FSH, LH) release. (It should be noted that more rapid, lower amplitude pulses of GnRH lead to increased LH/FSH secretion, while more irregular, larger amplitude pulses of GnRH leads to a decrease in the ratio of LH/FSH.) Increased FSH level causes growth of more ovarian follicles, and subsequently rupture of follicles resulting in ovulation. Ovulation occurs most often 6-7 days after a course of clomifene.


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