Product name: ClomifeneCitrateCapsules
MOQ: 1 Box
Status: Brand new, expiration date in 3 years
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4-7 days products arrive.
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Name: Clomifene inhibits estrogen receptors in hypothalamus,
inhibiting negative feedback of estrogen on gonadotropin release,
leading to up-regulation of the hypothalamic–pituitary–adrenal
axis. Zuclomifene, a more active isomer, stays bound for long
periods of time.
In normal physiologic female hormonal cycling, at 7 days past
ovulation, high levels of estrogen and progesterone produced from
the corpus luteum inhibit GnRH, FSH and LH at the hypothalamus and
anterior pituitary. If fertilization does not occur in the
post-ovulation period the corpus luteum disintegrates due to a lack
of beta-hCG. This would normally be produced by the embryo in the
effort of maintaining progesterone and estrogen levels during
Therapeutically, clomifene is given early in the menstrual cycle.
It is typically prescribed beginning on day 5 and continuing for 5
days. By that time, FSH level is rising steadily, causing
development of a few follicles. Follicles in turn produce the
estrogen, which circulates in serum. In the presence of clomifene,
the body perceives a low level of estrogen, similar to day 22 in
the previous cycle. Since estrogen can no longer effectively exert
negative feedback on the hypothalamus, GnRH secretion becomes more
rapidly pulsatile, which results in increased pituitary
gonadotropin (FSH, LH) release. (It should be noted that more
rapid, lower amplitude pulses of GnRH lead to increased LH/FSH
secretion, while more irregular, larger amplitude pulses of GnRH
leads to a decrease in the ratio of LH/FSH.) Increased FSH level
causes growth of more ovarian follicles, and subsequently rupture
of follicles resulting in ovulation. Ovulation occurs most often
6-7 days after a course of clomifene.